Preheat the air fryer:
Set your air fryer to 375°F (190°C) and allow it to preheat for about 5 minutes.
Prepare the meatloaf mixture:
In a large bowl, combine the ground beef, breadcrumbs, milk, egg, onion, garlic, Worcestershire sauce, salt, pepper, and Italian seasoning. Mix gently until everything is just combined—avoid overmixing to keep the meatloaf tender.
Shape the meatloaf:
Shape the mixture into a loaf approximately 6 inches long and 3 inches wide. If needed, line the air fryer basket with foil or parchment paper and place the meatloaf on top.
Cook the meatloaf:
Place the meatloaf in the air fryer basket and cook for 15 minutes.
Make the glaze:
While the meatloaf cooks, mix the ketchup, brown sugar, and Dijon mustard in a small bowl until smooth.
Glaze and finish cooking:
After 15 minutes, carefully brush the meatloaf with the glaze. Return it to the air fryer and cook for another 10–15 minutes, or until the internal temperature reaches 160°F (71°C).
Rest and serve:
Allow the meatloaf to rest for 5 minutes before slicing. Serve with mashed potatoes, green beans, or your favorite sides.